Lariam

Pronunciation: ME-floe-kwin
Generic Name: Mefloquine
Brand Name: Generic only. No brands available.

Lariam is used for:

Treating or preventing malaria.

Lariam is an antimalarial agent. Exactly how it works to kill sensitive malaria parasites is not known.

Do NOT use Lariam if:

• you are allergic to any ingredient in Lariam or to a similar medicine (eg, quinine, quinidine)


• you do not already have malaria and you currently have depression, a recent history of mental illness (eg, anxiety disorder, depression, psychosis, schizophrenia) or a history of seizures


• you are taking chloroquine, halofantrine, ketoconazole, quinidine, or quinine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lariam:

Some medical conditions may interact with Lariam. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of seizures, heart problems (eg, irregular heartbeat), blood clotting problems, liver problems, diabetes, mental or mood problems (eg, depression), or suicidal thoughts or actions


• if you are taking medicine for diabetes (eg, glyburide) or an anticoagulant (eg, warfarin)


• if you are scheduled to receive a vaccine

Some MEDICINES MAY INTERACT with Lariam. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, propafenone, quinidine), certain antihistamines (eg, astemizole, terfenadine), beta-blockers (eg, propranolol), calcium channel blockers (eg, amlodipine, verapamil), chloroquine, dofetilide, halofantrine, hydroxychloroquine, ketoconazole, paliperidone, phenothiazines (eg, thioridazine), quinine, tricyclic antidepressants (eg, amitriptyline), or ziprasidone because the risk of heart problems (eg, irregular heartbeat) or seizures may be increased


• Anticoagulants (eg, warfarin) because the risk of bleeding may be increased


• Rifampin because it may decrease Lariam's effectiveness


• Anticonvulsants (eg, valproic acid, carbamazepine, phenobarbital, phenytoin) because their effectiveness may be decreased by Lariam

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lariam may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine

How to use Lariam:

Use Lariam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lariam comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Lariam refilled.


• Take Lariam by mouth with a full glass of water (8 oz/240 mL) right after you eat your main meal. Do not take it on an empty stomach.


• If the tablets cannot be swallowed whole, they may be crushed and mixed with a small amount of water, milk, or other beverage. Be sure to drink all the liquid so that you receive the entire dose.


• Lariam may cause vomiting, especially in children. Check with your doctor to see if you should take another dose if you vomit after taking Lariam.


• If you are taking Lariam to prevent malaria, begin taking it 1 week before traveling. Continue to take it for 4 weeks after leaving the malaria area. If you cannot complete the treatment, contact your doctor.


• If you are taking other medicines, ask your doctor if you should start taking Lariam 2 to 3 weeks before traveling in order to make sure that the combination of medicines is well tolerated.


• Weekly doses of Lariam should be taken regularly, on the same day of each week, preferably after the main meal of the day.


• Continue to use Lariam for the full course of treatment. Do not miss any doses. Malaria can be life-threatening.


• If you miss a dose of Lariam and you are taking it to prevent infection, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lariam.

Important safety information:

• Lariam may cause drowsiness, dizziness, lightheadedness, or a loss of balance. These effects may be worse if you take it with alcohol or certain medicines. Effects of Lariam may continue for a period of time (eg, several weeks), even after you stop taking it. Use Lariam with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Carry an ID card at all times that says you take Lariam.


• Tell your doctor or dentist that you take Lariam before you receive any medical or dental care, emergency care, or surgery.


• Lariam may decrease the effectiveness of live vaccines. Check with your doctor before you receive any vaccines while you are using Lariam.


• Women who may become pregnant should use effective birth control while taking Lariam and for up to 3 months after stopping treatment. Check with your doctor if you have questions about using birth control.


• Contact your doctor right away if you experience mental or mood changes (eg, anxiety, depression, restlessness, confusion, hallucinations, paranoia). You may need to stop taking Lariam and start a different malaria medicine.


• If you have to stop taking Lariam for any reason and you do not have access to a doctor or to another malaria medicine, leave the malaria area and contact a doctor as soon as possible. Leaving the area may not protect you from contracting malaria. You may still need to take another medicine to prevent the disease.


• No medicine is completely effective against malaria. While you are in an area where malaria exists, use bed nets and insect repellents and wear protective clothing (long sleeves and long pants) to decrease your risk. In some situations, you may want to pre-wash your clothes with permethrin, a mosquito repellent that may be effective for weeks after use. Ask your doctor for other ways to protect yourself.


• Contact your health care provider at once if you develop a fever or flu-like symptoms (eg, chills, headache, muscle pains) after returning from an area where malaria exists.


• If you are using Lariam to treat malaria and your symptoms do not improve within 48 to 72 hours, contact your doctor right away.


• If your doctor tells you to stop taking Lariam, you will need to wait for at least 15 weeks before you start to take certain other medicines (eg, halofantrine, ketoconazole). Ask your doctor when you should start to take any new medicines after you stop Lariam.


• Lab tests, including liver function, complete blood cell count, and eye exams, may be performed while you use Lariam. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Lariam with caution in the ELDERLY; they may be more sensitive to its effects, especially heart problems.


• Lariam should not be used in CHILDREN who are younger than 6 months old or who weigh less than 44 lbs (20 kg); safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not become pregnant while you are taking Lariam. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lariam while you are pregnant. Lariam is found in breast milk. Do not breast-feed while taking Lariam.

Possible side effects of Lariam:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache; lightheadedness; loss of appetite; muscle aches; nausea; stomach pain or upset; strange dreams; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; chest pain; fainting; fast, slow, or irregular heartbeat; flu-like symptoms (eg, chills, fever, headache, muscle pain); loss of balance or coordination; memory problems; mental or mood changes (eg, anxiety, confusion, depression, hallucinations, mood changes, paranoia, restlessness); numbness or tingling of the hands or feet; red, swollen or blistered skin; ringing in the ears; seizures; severe or persistent cough; shortness of breath; suicidal thoughts or attempts; symptoms of liver problems (eg, dark urine, pale stools, persistent stomach pain or loss of appetite, persistent tiredness, yellowing of the skin or eyes); tremor; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lariam side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fast, slow, or irregular heartbeat; mental or mood changes; vomiting.

Proper storage of Lariam:

Store Lariam at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep out of the reach of children and away from pets.

General information:

• If you have any questions about Lariam, please talk with your doctor, pharmacist, or other health care provider.


• Lariam is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lariam. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Lariam resources

• Lariam Side Effects (in more detail)
• Lariam Use in Pregnancy & Breastfeeding
• Drug Images
• Lariam Drug Interactions
• Lariam Support Group
• 0 Reviews for Lariam - Add your own review/rating

• Lariam Prescribing Information (FDA)


• Lariam Advanced Consumer (Micromedex) - Includes Dosage Information


• Lariam Concise Consumer Information (Cerner Multum)


• Lariam Monograph (AHFS DI)


• Mefloquine Prescribing Information (FDA)

Compare Lariam with other medications

• Malaria
• Malaria Prevention