Lumizyme

Pronunciation: AL-gloo-KOE-si-dase
Generic Name: Alglucosidase Alfa
Brand Name: Examples include Lumizyme and Myozyme

Lumizyme may cause severe allergic reactions, including anaphylactic shock. The reaction may occur while you receive Lumizyme or up to several hours after. Tell your health care provider immediately if you experience rash; hives; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness while receiving Lumizyme. Only use Lumizyme where appropriate measures to treat a severe allergic reaction are available.

Certain brands of Lumizyme are only available through a restricted distribution program. Patients who receive certain brands of Lumizyme must be enrolled and meet all the conditions of this program.

Lumizyme is used for:

Treating Pompe disease (alfa-glucosidase deficiency) in certain patients.

Lumizyme is a glycoprotein. It works by replacing the enzyme alfa-glucosidase in the body.

Do NOT use Lumizyme if:

• you are allergic to any ingredient in Lumizyme

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lumizyme:

Some medical conditions may interact with Lumizyme. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have ever had a reaction (eg, swelling, trouble breathing) to any intravenous (IV) medicine


• if you are or have recently been ill


• if you have heart problems (eg, enlarged heart) or lung problems

Some MEDICINES MAY INTERACT with Lumizyme. However, no specific interactions with Lumizyme are known at this time.

Ask your health care provider if Lumizyme may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lumizyme:

Use Lumizyme as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lumizyme will be given as an injection at your doctor's office, hospital, or clinic.


• Do not use Lumizyme if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• Continue to use Lumizyme even if you feel well. Do not miss any doses.


• If you miss a dose of Lumizyme, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Lumizyme.

Important safety information:

• Tell your doctor or dentist that you use Lumizyme before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including liver function and immune system, may be performed while you use Lumizyme. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Certain brands of Lumizyme should only be used for specific types of Pompe disease. Check with you doctor if you have any questions about this information.


• Caution is advised when using Lumizyme in CHILDREN; they may be more sensitive to its effects.


• Certain brands of Lumizyme should be used with extreme caution in CHILDREN younger than 8 years old; safety and effectiveness in these children have not been confirmed. Check with your doctor if you have questions about this information.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lumizyme while you are pregnant. It is not known if Lumizyme is found in breast milk. If you are or will be breast-feeding while you use Lumizyme, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Lumizyme:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; heartburn; runny nose; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); agitation, irritability, or restlessness; blue skin or nails; chest pain or tightness; chills; cold hands or feet; cough; ear pain; excessive or cold sweat; fast, slow, or irregular heartbeat; feeling hot; fever; flushing; headache; hearing changes; increased tear production; muscle pain, stiffness, or twitching; nausea; nosebleed; pain, swelling, or redness at the injection site; pale skin; purplish skin discoloration; rapid or difficult breathing; severe headache, dizziness, or vomiting; shortness of breath; sore throat; stomach or back pain; swelling of the hands, legs, or feet; throat tightness; tremor; unexplained cough; unusual tiredness or weakness; vision changes; wheezing; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lumizyme side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Lumizyme:

Lumizyme is usually handled and stored by a health care provider. If you are using Lumizyme at home, store Lumizyme as directed by your pharmacist or health care provider. Keep Lumizyme out of the reach of children and away from pets.

General information:

• If you have any questions about Lumizyme, please talk with your doctor, pharmacist, or other health care provider.


• Lumizyme is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lumizyme. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Lumizyme resources

• Lumizyme Side Effects (in more detail)
• Lumizyme Use in Pregnancy & Breastfeeding
• Lumizyme Support Group
• 0 Reviews for Lumizyme - Add your own review/rating

• Lumizyme Consumer Overview


• Lumizyme Advanced Consumer (Micromedex) - Includes Dosage Information


• Lumizyme Prescribing Information (FDA)


• Alglucosidase Alfa Professional Patient Advice (Wolters Kluwer)


• Alglucosidase Alfa Monograph (AHFS DI)


• Myozyme Prescribing Information (FDA)


• Myozyme Consumer Overview

Compare Lumizyme with other medications

• Pompe disease